Trends in Incidence and Predictors of Incident Venous Thromboembolism in Patients with Rheumatoid Arthritis: A Population-Based Retrospective Cohort Study
Abstract format and assignment number: Oral presentation OP0070
Presenting author: E Myasoedova (USA)
Date: Wednesday 11th June 2025, 17:20
This population-based study showed that patients with rheumatoid arthritis (RA) had a significantly increased risk of deep vein thrombosis (DVT) and pulmonary embolism (PE) compared to controls. Risk factors included age, obesity, smoking, high disease activity and biologic use in the first year. Remission was protective for PE. Despite therapeutic advances, VTE risk in RA has not declined since the 2000s, highlighting the need for improved prevention strategies.
Does the amount of genetic predisposition to RA influence the risk of myocardial infarction?
Abstract format and assignment number: Oral presentation OP0072
Presenting author: J Askling (Sweden)
Date: Wednesday 11th June 2025, 17:30
This Swedish study explored whether genetic predisposition to rheumatoid arthritis (RA) increases myocardial infarction (MI) risk. Among 8,707 individuals (with and without RA), RA was associated with higher MI incidence. However, polygenic risk scores (PRS) for RA were not linked to MI risk in any group. These findings suggest that the familial aggregation of RA and MI is likely driven by non-genetic factors, emphasising the role of traditional cardiovascular risk management.
Clinical and functional distinctions between late-onset and young-onset rheumatoid arthritis in older female patients
Abstract format and assignment number: Oral presentation OP0191
Presenting author: Y Saito (Japan)
Date: Thursday 12th June 2025, 10:40
This study compared older female patients with late-onset RA (LORA) versus young-onset RA (YORA). Despite similar physical performance and sarcopenia rates, LORA patients had milder joint damage, shorter disease duration, lower RF positivity and better muscle quality as indicated by higher phase angle values. These findings suggest LORA patients may have a more favourable functional prognosis and highlight phase angle as a valuable marker for muscle quality in RA.
Identification of intestinal biomarkers for evaluating disease activity in rheumatoid arthritis
Abstract format and assignment number: Oral presentation OP00196
Presenting author: N Wang (China)
Date: Thursday 12th June, 11:30
This multicentre study identified intestinal biomarkers (sCD14, LBP and I-FABP) as elevated in RA patients compared to healthy controls. Their combined use showed high accuracy in diagnosing RA (AUC=0.936) and predicting disease activity (AUC=0.794). sCD14 was independently associated with active synovitis and correlated with DAS28 scores and inflammatory markers, supporting the role of gut barrier dysfunction in RA pathogenesis and monitoring.
Do RA risk factors also affect the speed of clinical RA onset?
Abstract format and assignment number: Oral presentation OP0326
Presenting author: C Grönwall (Sweden)
Date: Friday 13th June 2025, 11:00
This Swedish study explored whether known RA risk factors influence the time from symptom onset to RA diagnosis. In 2,229 patients (primarily seropositive), factors such as sex, smoking, shared epitope status and polygenic risk scores did not significantly affect diagnostic delay. Median time to diagnosis remained consistent (~5 months), suggesting that while these factors may drive disease risk, they do not appear to influence the speed of clinical RA onset.
Roba Ghossan
Roba is a rheumatologist at the Department of Rheumatology of Cochin Hospital APHP in Paris, France. Her main clinical and research interests include inflammatory rheumatic diseases, musculoskeletal ultrasound and epidemiology.
Roba is a member of the French Society of Rheumatology and the society’s young rheumatologists section (REF). She is a member of the EMEUNET Visibility and Global Affairs Sub-Committee.