EULAR 2026: Do Not Miss- Basic and Translational Research I

Bohdana Doskaliuk

Country: Ukraine
Bohdana is an Associate Professor at Ivano-Frankivsk National Medical University. Her PhD research focused on pulmonary involvement in systemic sclerosis and its potential correction.
Bohdana actively contributes also as a reviewer and editor. She serves as an Associate Editor for Rheumatology International and is the Editorial Board member for Therapeutic Advances in Musculoskeletal Disease and Rheumatology Advances in Practice. She is also affiliated with the European Academy of Allergy and Clinical Immunology and European Respiratory Society. Bohdana is a Country Liaison Sub-Committee member.

Oral presentation OP0175 | Thursday 04.06.2026 08:45
Basic and Clinical Abstract Sessions: Insights into bone health – what are the drivers?
Author:  Chenjia He (China)
Title: Spp1+ macrophages are specifically enriched in arthritic joints and associated with abnormal bone metabolism in collagen-induced arthritis mice

It highlights the joint-specific enrichment of pathogenic Spp1+ macrophages in collagen-induced arthritis and their association with bone destruction. Using scRNA-seq, flow cytometry, and micro-CT, the study shows that these macrophages are increased in inflamed joints but not peripheral blood or spleen. Their correlation with reduced bone volume and trabecular damage suggests a mechanistic link between macrophage-driven inflammation and structural joint deterioration in RA.
Oral presentation OP0179 | Thursday 04.06.2026 09:15
Basic and Clinical Abstract Sessions: Insights into bone health – what are the drivers?
Author: Maxime Auroux (France)
Title: Erosive hand osteoarthritis is associated with increased risk of incident osteoporotic fractures in post-menopausal women

This study highlights erosive hand osteoarthritis as a distinct phenotype associated with increased osteoporotic fracture risk in postmenopausal women. Unlike radiographic or symptomatic non-erosive hand OA, ErHOA nearly doubled the risk of incident osteoporotic fractures independently of age, BMD, prior fractures, obesity, and sarcopenia. The association was not explained by accelerated bone loss, suggesting a direct disease-related mechanism linking erosive joint pathology with skeletal fragility.
Poster presentation POS0965 | Friday 05.06.2026 13:30
Poster View VI
Author:  Amber Dassen (Netherlands)
Title: Advancement of 3-dimensional synovial tissue organoids into a personalized drug-testing platform for rheumatoid arthritis

This study presents a novel 3D organoid model replicating the human synovial microenvironment using patient-derived fibroblasts and macrophages. The model mimics inflammation seen in arthritis and reveals key cytokine responses, offering insights into individual disease mechanisms. It holds promise for personalized the rapydevelopment and improves uponthe predictive limitations oftraditional 2D cultures andanimal models.​
Oral presentation OP025| Friday 05.06.2026 15:45
How do cells build their home – structural immunity in RA
Author:  Shehzahdi Moonshi (Australia)
Title: Optimised antigen-specific immunotherapy liposomes enable immune regulation and sustained disease control in experimental arthritis

It highlights the joint-specific enrichment of pathogenic Spp1+ macrophages in collagen-induced arthritis and their association with bone destruction. Using scRNA-seq, flow cytometry, and micro-CT, the study shows that these macrophages are increased in inflamed joints but not peripheral blood or spleen. Their correlation with reduced bone volume and trabecular damage suggests a mechanistic link between macrophage-driven inflammation and structural joint deterioration in RA.
Oral presentation OP029 | Saturday 06.06.2026 09:45
Advancing Global Health in Rheumatology: Building Capacity, Equity, and Resilience Across Borders
Author:  Rodolfo Martinez-Canales (Mexico)
Title: Inequities in global representation and transparency in transcriptomic studies of systemic lupus erythematosus: a systematic assessment of public datasets

It highlights a major equity and transparency gap in SLE transcriptomic research. Most publicly available datasets come from high-income countries, with virtually no representation from low- and lower-middle-income countries, and ethnicity is frequently unreported. This limits the generalizability of molecular findings, biomarker discovery, and therapeutic translation. The study emphasizes the need for standardized demographic reporting and more globally representative transcriptomic datasets.

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