ACR Convergence 2023: Do Not Miss – Basic and translational research I: Genetics, cartilage, osteoimmunology, and animal models

Bohdana Doskaliuk
Bohdana D. is a PhD fellow at the Ivano-Frankivsk National Medical University, Ukraine. Her main research interests include the pathogenesis of SSc-ILD and animal models of rheumatic diseases. Bohdana D. is a member of the EMEUNET Country Liasson Sub-Committee.

Poster 0014 | Sunday, 12.11.23 09.00
Poster Session A (Genetics, Genomics & Proteomics Poster)
Author: Laurynenka, V (USA)
Title: THE 330 GENETIC RISK LOCI OF SYSTEMIC LUPUS ERYTHEMATOSUS (SLE) NOW KNOWN ARE CONSONANT WITH MULTIPLE CAUSAL MECHANISMS INVOLVING EPSTEIN-BARR VIRUS (EBV)-ENCODED TRANSCRIPTION CO-FACTORS (TFS) IN EBV-INFECTED B CELLS

It presents connection between EBV infection and SLE autoimmunity, revealing shared genetic mechanisms and highlighting the role of EBV-transformed B cells in SLE development.
Poster 0020 | Sunday, 12.11.23 09.00
Poster Session A (Genetics, Genomics & Proteomics Poster)
Author: Sequí-Sabater, JM (Spain)
Title: THE INFLAMMATORY PROTEOME IN SJÖGREN’S SYNDROME IDENTIFIES NEW BIOMARKERS AND RELEVANT CLINICAL SUBGROUPS

It recognizes the unique molecular patterns in individuals suffering from primary Sjögren’s syndrome.
Oral 1668 | Monday, 13.11.23 16.00
Abstracts Session (Systemic Sclerosis & Related Disorders – Basic Science)
Author: Yang, M (USA)
Title: CELL SPECIFIC MOLECULAR PROFILING OF SCLERODERMA ASSOCIATED INTERSTITIAL LUNG DISEASE SUBTYPES

It reveals variations in cellular composition and molecular pathways, highlighting potential insights into the pathogenesis of SSD-ILD.
Oral 1595 | Monday, 13.11.23 14.00
Abstract session (Osteoarthritis & Joint Biology – Basic Science)
Author: Kawata, M (USA)
Title: PHARMACOLOGICAL MODULATION OF KRÜPPEL-LIKE FACTOR 4 REDUCES THE SEVERITY OF EXPERIMENTAL OSTEOARTHRITIS VIA TISSUE PROTECTION AND REGENERATION

It highlights mocetinostat, a class I histone deacetylase (HDAC) inhibitor, as a promising OA treatment candidate.
Poster 1733 | Tuesday, 14.11.23 09.00
Poster Session C (RA – Animal Models Poster)
Author: Aripova, N (UK)
Title: PLATELET-DERIVED GROWTH FACTOR IS A MEDIATOR OF DISEASE IN AN ANIMAL MODEL OF RHEUMATOID-ASSOCIATED INTERSTITIAL LUNG DISEASE

It indicates a potential for developing novel treatments targeting PDGF-BB in RA-ILD, addressing a critical unmet need in the field.
Oral 2438 | Tuesday, 14.11.23 14.00
Abstract Session (Spondyloarthritis Including Psoriatic Arthritis – Basic Science)
Author: Tynan, O (Ireland)
Title: SYNOVIAL TISSUE SINGLE-CELL ANALYSIS DEMONSTRATES DIFFERENTIAL FIBROBLAST POPULATIONS BETWEEN RA AND PSA WHICH DISPLAY DISTINCT FUNCTION

It highlights differences in synovial fibroblasts’ phenotypes, functionality, and disease-related pathways in RA and PsA.

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