Steph is a rheumatology specialist trainee and NIHR Academic Clinical Lecturer in Manchester, UK. Her main research interests include the use of multi-omics analysis to define biomarkers of treatment response in RA and pharmacological modelling and simulation. Steph is a member of the EMEUNET Newsletter Sub-Committee.
|Poster 0002 | Sunday, 12.11.23 09:00|
B Cell Biology & Targets in Autoimmune and Inflammatory Disease Poster
Author: Wang, X (USA)
Title: POPULATION PHARMACOKINETIC AND PHARMACODYNAMIC ANALYSES OF OBEXELIMAB IN HEALTHY VONLUNTEERS AND IN PATIENTS WITH RHEUMATOID ARTHRITIS OR IGG4-RELATED DISEASES
This study demonstrates the utility of the dual-target antibody obexelimab in inhibiting B cells and C19 receptors occupancy in both health and pathology (RA and IgG4-RD). Of particular interest, the most parsimonious simulated model was for subcutaneous, rather than intravenous administration.
|Oral 0724 | Sunday, 12.11.23 11:00|
Author: Bell, R (USA)
Title: SYNOVIAL MACROPHAGE SUBSETS DEFINED BY SCRNASEQ DEMONSTRATE SEXUALLY MIMORPHIC GENE EXPRESSION IN RA AND A MOUSE INFLAMMATORY ARTHRITIS MODEL
This study helps to explain clinical sex dimorphism in RA phenotypes by using scRNAseq from RA synovial biopsies obtained from the AMP-RA consortium, as well as mouse models.
|Oral 0732 | Sunday, 12.11.23 14:00|
Abstracts: B Cell Biology & Targets in Autoimmune & Inflammatory Disease
Author: Ghossan, R (France)
Title: SHOULD COMPLETE B-CELL DEPLETION BE MAINTAINED IN PATIENTS TREATED LONG-TERM WITH RITUXIMAB FOR RHEUMATOID ARTHRITIS?
The authors found that whilst complete B cell depletion is associated with better rituximab response at initiation, it is not associated with better efficacy in the long-term. They advocate against CD19 monitoring long-term.
|Oral 0792 | Sunday, 12.11.23 14:00|
Abstracts: Systemic Sclerosis & Related Disorders I: Translational
Author: Ainsworth, R (USA)
Title: SINGLE CELL RNA-SEQ OF MYELOID CELLS FROM SYSTEMIC SCLEROSIS PATIENTS IDENTIFIES CIRCULATING MONOCYTE POPULATION WITH INTERFERON SIGNATURE ASSOCIATED WITH INTERSTITIAL LUNG DISEASE
Altered myeloid cell numbers and functions have been implicated in the initiation and progression of SSc. The authors identified a novel cluster of monocytes from peripheral blood expressing high levels of type I IFN-inducible markers that was associated with SSc-ILD.
|Poster 0884 | Monday, 13.11.23 09:00|
Osteoarthritis & Joint Biology – Basic Science Poster
Author: Younis, S (USA)
Title: IDENTIFICATION OF A MAST CELL-HIGH SYNOVIAL PATHOTYPE OF OSTEOARTHRITIS
The authors used multiple methods to examine OA synoviocytes in detail. They then showed that blockade of histamine activity reduced development of OA in mice, and they suggested that targeting histamine can potentially benefit subsets of OA.
|Oral 2511 | Tuesday, 14.11.23 16:00|
Abstracts: Immunological Complications of Medical Therapy
Author: Ammitzbøll, C (Denmark)
Title: SUPERIOR SARS-COV-2 ANTIBODY RESPONSE ACHIEVED IN RITUXIMAB-TREATED PATIENTS WHEN VACCINATED AGAINST COVID-19 BEFORE COMPARED TO AFTER RITUXIMAB INITIATION – GUIDANCE FOR FUTURE VACCINATION STRATEGIES
The authors propose vaccination timing strategies in relation to rituximab dosing, adding to the debate of this contentious hot topic in the management of IMIDs .