Miranda van Lunteren PhD
Miranda is a post-doctoral clinical researcher and clinical study coordinator at Department of Rheumatology of the Leiden University Medical Center in Leiden. In 2020, she obtained her PhD on the burden of early axial spondyloarthritis. Her major research interest is axial spondyloarthritis, with a focus on observational studies, imaging and patient-reported outcomes. She has an interest in methodology and clinical trials. Miranda is the study coordinator of the ASAS CLASSIC study, a member of the Y-ASAS Website Subgroup and of the EMEUNET Social Media Sub-Committee.
| Poster 0551 | Saturday, 16.11.24 10:30 SpA Including PsA – Diagnosis, Manifestations, & Outcomes Poster I Presenting author: D Capelusnik (Israel) Title: Evaluation of Instruments Assessing Peripheral Arthritis in Spondyloarthritis: An Analysis of the ASAS-perSpA Study  This study used the ASAS-PerSpA study to evaluate the construct validity of various disease activity instruments for assessing peripheral arthritis in spondyloarthritis (SpA). Analyzing data from 4,121 patients, all instruments demonstrated excellent correlation with external constructs and known-group discrimination. Composite scores including joint scores, such as DAPSA and DAS28, showed the highest ability to distinguish between active and inactive disease. |
| Poster 0569 | Saturday, 16.11.24 10:30 SpA Including PsA – Diagnosis, Manifestations, & Outcomes Poster I Presenting author: S Ramiro (the Netherlands) Title: The Longitudinal Association Between Disease Activity, Function and Health-Related Quality of Life in Axial Spondyloarthritis: Results from the DESIR Cohort This study investigated the longitudinal relationships between disease activity, physical function, and health-related quality of life (HRQoL) in patients with axial spondyloarthritis (axSpA). Analyzing 10-year data from 663 patients in the DESIR cohort, significant associations were found between disease activity (ASDAS) and physical function (BASFI) with various HRQoL measures (mental and physical component of SF36, ASQoL). The findings confirm that HRQoL serves as an overarching outcome, influenced by disease activity and function in axSpA. |
| Oral 0818 | Saturday, 16.11.24 13:15 Abstracts: SpA Including PsA – Diagnosis, Manifestations, & Outcomes I Author: S Georgiadis (Denmark) Title: Defining BASDAI Cut-offs for Disease Activity States in Axial Spondylarthritis – Results from the EuroSpA Collaboration This study aimed to establish BASDAI cut-offs for disease activity states against predefined external critera and assess the agreement with ASDAS disease activity states in patients with axial spondyloarthritis (axSpA). Analyzing data from 2,791 patients, optimal BASDAI cut-offs were determined as <1.4 between remission and low disease activity, <2.8 between low and high, and >5.9 between high and very high disease activity. Moderate agreement was found between BASDAI and ASDAS disease activity states, indicating differences in the underlying assessed domains. |
| Oral 0819 | Saturday, 16.11.24 13:30 Abstracts: SpA Including PsA – Diagnosis, Manifestations, & Outcomes I Presenting author: D Poddubnyy (Germany) Title: The Assessment of SpondyloArthritis International Society (ASAS) Definition of Difficult-to-Manage Axial Spondyloarthritis ASAS aimed to define “difficult-to-manage axSpA” (D2M axSpA) due to challenges with non-responsiveness to standard treatment. A literature review and a two-round Delphi consensus involving professional and patient input led to a definition encompassing treatment failure, suboptimal disease control, and acknowledgment of problematic signs/symptoms by the rheumatologist and/or patient. The definition, endorsed by 89% of voting ASAS members, facilitates better identification of patients with non-response to current standard treatments, supporting future research. |
| Oral 0820 | Saturday, 16.11.24 13:45 Abstracts: SpA Including PsA – Diagnosis, Manifestations, & Outcomes I Presenting author: W Maksymowych (Canada) Title: The Classification in Axial Spondyloarthritis Inception Cohort Study: Performance of the 2009 Assessments in Spondyloarthritis International Society Classification Criteria This worldwide study of 1,015 patients showed that the 2009 ASAS classification criteria obtained a sensitivity varying from 73.8-82.4% and specificity from 77.1-84.3%, depending on using local/central imaging reading and stage 4 and 5 (after) global diagnostic evaluation (before/after central imaging reading). The set targets of 75% sensitivity and 90% specificity were not validated, indicating the need for revision of the classification criteria. |
| Poster 1438 | Sunday, 17.11.24 10:30 SpA Including PsA – Diagnosis, Manifestations, & Outcomes Poster II Author: S Ramiro (the Netherlands) Title: Performance of Combined MRI SI Joint Active and Structural Lesions in Diagnosing Axial SpA: A Prospective Cohort Study The predictive validity of different combinations of definitions for active and structural lesions on the MRI of the SI-joints (MRI-SIJ) in axial spondyloarthritis (axSpA) was evaluated. Analyzing 643 patients of the SPACE cohort, the ASAS-MRI-SIJ+ definition demonstrated superior sensitivity compared to the new MRI study group definition for active lesions. While structural lesions alone offered a minimal gain in sensitivity, the combination of ASAS-MRI-SIJ+ (active lesions) and de Hooge (structural lesions) performed best to identify patients with short symptom duration. |
| Poster 2334 | Monday, 18.11.24 10:30 SpA Including PsA – Diagnosis, Manifestations, & Outcomes Poster III Presenting author: M Torgutalp (Germany) Title: Characteristics of Patients with Psoriatic Arthritis Presenting with Axial Involvement: Results of a Prospective International Multicenter Study (AXIS) The AXIS cohort study evaluated axial involvement in psoriatic arthritis (PsA) across 19 countries worldwide. Of 409 participants, initial assessments of the local investigators suggested axial involvement in 37.4%, which dropped to 27.4% after expert imaging reviews. Factors associated with axial involvement included inflammatory back pain, HLA-B27 positivity, elevated CRP levels and active inflammatory and structural changes in the sacroiliac joints and spine. The study highlights the need for improved classification criteria for axial involvement in PsA. |