Treg Expansion and IL-6 Induced STAT3 Phosphorylation in CD4+ T Cells Is a Biomarker of Disease Flare in Rheumatoid Arthritis
Abstract format and assignment number: Poster 1845
Presenting author: Amy Anderson (UK)
Date: Monday, 18th November 2024
This study identifies elevated naive CD4+ T cells expressing pSTAT3 and increased Treg proportions as predictors of rheumatoid arthritis (RA) flare or drug-free remission (DFR) after DMARD withdrawal. Flare patients exhibited rising pSTAT3 levels in Tregs, driven by IL-6 and LIF, potentially impairing Treg function. These findings reveal pathways linked to RA flare and suggest targets for therapeutic intervention.
Clock Gene Bmal1 Contributes to Inflammation via Phosphorylation of NF-κB/p65 in RA-FLS
Abstract format and assignment number: Oral presentation 2596
Presenting author: Hikari Tsukamoto (Japan)
Date: Monday, 18th November 2024
This study reveals that clock gene BMAL1 promotes inflammation in rheumatoid arthritis by interacting with NF-κB/p65 and enhancing its transcriptional activity via phosphorylation at Ser536. Unlike the canonical pathway, this non-canonical mechanism does not involve IκBα degradation. These findings highlight BMAL1’s role in exacerbating RA inflammation, linking circadian rhythms to inflammatory disease progression.
Harnessing microRNA and Machine/Deep Learning for Early Prediction of Knee Osteoarthritis Structural Progression
Abstract format and assignment number: Poster 1202
Presenting author: Johanne Martel-Pelletier (Canada)
Date: Sunday, 17th November 2024
This abstract presents a novel miRNA-based predictive model for identifying knee osteoarthritis (OA) structural progressors. Using data from 152 participants, the model incorporated machine/deep learning techniques to optimize prediction. The final model required only five features, including age and specific miRNAs, achieving excellent performance (AUC: 0.94; accuracy: 0.84). Validation with independent cohorts confirmed robustness and generalizability. This predictive tool has potential translational applications in personalized OA management and monitoring.
Follicular Dendritic Cell PD-L1 Expression Promotes Autoreactive Germinal Center Formation
Abstract format and assignment number: Oral presentation 0776
Presenting author: Elliot Akama-Garren (USA)
Date: Saturday, 16th November 2024
It investigates the role of PD-L1 in germinal center (GC) responses, revealing its novel immunogenic, non-cell-autonomous function in tuning T-B cell collaboration. Using murine models and single-cell RNA sequencing of human and mouse lymphoid tissues, the study identifies PD-L1 on follicular dendritic cells (FDCs) and naïve B cells as critical for GC formation and autoreactive B cell regulation. These findings advance understanding of GC dynamics and PD-L1’s role in humoral immunity, with implications for autoimmunity and vaccine design.
Micro-RNAs as Biomarkers for Methotrexate Treatment Response in Patients with Psoriatic Arthritis
Abstract format and assignment number: Poster 0075
Presenting author: Darshini Ganatra (Canada)
Date: Saturday, 16th November 2024
It identifies novel miRNA biomarkers associated with methotrexate (MTX) response in psoriatic arthritis (PsA) patients. The study highlights miR-127-3p as a biomarker for predicting articular response and seven other miRNAs for cutaneous response. The predictive performance of miR-127-3p demonstrated high accuracy (AUC: 0.9 for articular response), validated in independent cohorts. These findings provide insights into personalized PsA treatment and hold promise for optimizing MTX therapy by minimizing ineffective treatments and joint damage.
Bohdana Doskaliuk, MD, PhD
Bohdana is an Assistant Professor at Ivano-Frankivsk National Medical University. Her PhD research focused on pulmonary involvement in systemic sclerosis and its potential correction.
Bohdana actively contributes also as a reviewer and editor. She serves as an Associate Editor for Rheumatology International and is the Editorial Board member for Therapeutic Advances in Musculoskeletal Disease and Rheumatology Advances in Practice. She is also affiliated with the European Academy of Allergy and Clinical Immunology and European Respiratory Society. Bohdana is a Country Liaison Sub-Committee member.
E-mail: doskaliuk_bo@ifnmu.edu.ua