Guillermo CARVAJAL ALEGRIA MD, PhD
Guillermo is professor of rheumatology at the University of Tours and in the rheumatology department of the Tours University Hospital, France. His research interests are polymyalgia rheumatica and giant cell arteritis, ultrasonography and procedures for clinical research and administration of biopharmaceuticals for scientific research. He is part of the board of directors of the French Rheumatology Society and of steering committee of the French College of Teaching Rheumatologists.
He is the chair of the EMEUNET Education sub-committee.
| Oral 0929| Sunday, 08.11.26 15:45 Abstracts: Vasculitis – ANCA-Associated – Clinical (0926-0931) Presenting author: YK. Kim (Korea) Title: Efficacy and safety of add-on glucocorticoid pulse therapy during remission induction in patients with ANCA-associated vasculitis: a target trial emulation study  This target trial emulation used a cohort of 247 patients with granulomatosis with polyangiitis or microscopic polyangiitis enrolled between 2004 and 2024. Remission (BVAS=0) at 12 months was similar with or without add-on glucocorticoid pulses during induction with rituximab or cyclophosphamide. Infections were more frequent in the pulse-treatment group.. |
| Oral 1858| Monday, 09.11.26 08:00 Abstracts: Sjögren’s Disease – Basic & Clinical Science (1856-1861) Presenting author: T. Grader-Beck (USA) Title: Salivary Gland Ultrasonography Severity Reflects Progressive Exocrine Dysfunction in Sjögren’s Disease This retrospective cohort study included 1,123 patients with Sjögren’s disease and OMERACT ultrasonography scoring of the major salivary glands. A grade of 3 in the most severely affected gland was associated with worse salivary flow, Schirmer test results and ocular staining scores than a grade of 0. The findings link greater ultrasonographic severity to more pronounced exocrine dysfunction. |
| Oral 1822| Monday, 09.11.26 10:30 Plenary II Presenting author: N. Yatim (France) Title: Clonal hematopoiesis orchestrates Giant Cell Arteritis Disease trajectory and immune landscape: a multicentric and multiomics approach This multicentre study found clonal haematopoiesis (CH) in approximately 50% of 260 patients with giant cell arteritis (GCA). CH was associated with relapse risk and a trend towards ischaemic manifestations. Transcriptomic and spatial transcriptomic analyses suggest links between CH and the vascular immune mechanisms of GCA. |
| Oral 1985| Monday, 09.11.26 13:45 Abstracts: Vasculitis – Non-ANCA-Associated & Related Disorders – Clinical (1892-1897) Presenting author: A. Dua (USA) Title: Effectiveness of Sarilumab versus Methotrexate as Glucocorticoid-sparing Therapy in Polymyalgia Rheumatica This retrospective database study compared 258 patients with polymyalgia rheumatica treated with sarilumab with matched methotrexate initiators. Median time to glucocorticoid discontinuation was shorter, and cumulative glucocorticoid exposure was lower, in the sarilumab group. These real-world findings support a glucocorticoid-sparing benefit of sarilumab, while recognising the observational design. |
| Oral 2857 Tuesday, 10.11.26 13:00 Abstracts: Epidemiology & Public Health II (2857-2862) Presenting author: J. Galloway (UK) Title: The impact of idiopathic inflammatory myopathies: A population-based cohort in England 2002 to 2021 This UK population-based cohort identified 4,097 patients with idiopathic inflammatory myopathies. Mortality and cancer risks were higher than in controls during the first year after diagnosis. During subsequent follow-up of 2–19 years, the risks remained elevated without further increase. The study highlights sustained adverse outcomes, including excess cancer risk, in this population |