Basic and Translational Research I

Aggelos Banos

Aggelos is a rheumatology resident physician and a junior researcher at Biomedical Research Foundation of the Academy of Athens. His major research interests include SLE and vasculitides (clinical aspects, outcomes, genetics, molecular taxonomy). Aggelos is a member of the Country Liaison Sub-Committee.

Type, n°Date, timeSessionAuthorTitle
Poster
0420
Wednesday, 31.05.2023
15:30 –
16:30
Bone diseases, aetiology, pathology
and animal models 
Pfeiffen-
berger, M
(Germany)
GENERATION OF A HUMAN 3D IN VITRO BONE MODEL THAT MIMICS GLUCOCORTICOID-INDUCED OSTEOPOROSIS
A severe clinical burden, as glucocorticoid-induced osteoporosis, is tackled by utilization of differentiation of mesenchymal stem cell towards construction of an in vitro 3D scaffold of the human bone.
Oral
0105
Thursday,
01.06.2023
10:45 – 
10:55
Innate Immunity in Pathogenesis
of RMDs 
Altaie, A 
(UK)
SINGLE CELL RNASEQ AND FUNCTIONAL STUDIES SUGGEST A ROLE FOR ENTHESIS MESENCHYMAL STEM CELLS RATHER THAN TREGS IN ENTHESIS SOFT TISSUE AND BONE ANCHORAGE SITE IMMUNOMODULATION
Molecular characterization of enthesis and a functional cell map are studied through novel –omics approach
Oral  
0099
Friday,
02.06.2023
11:05 –
11:15
Genetics and EpiGenetics of RMDs Shi, C
(UK)
UNVEILING THE COMPLEX GENE REGULATORY MECHANISMS OF PSORIATIC ARTHRITIS THROUGH CHROMATIN CONFORMATION, GENE EXPRESSION AND CHROMATIN ACCESSIBILITY ANALYSIS IN PRIMARY CELLS
Tight and simultaneously adaptive transcriptional regulation of the gene circuit governing molecular traits of psoriatic arthritis is multi-way depicted in this study.
Poster
1044
Friday,
02.06.2023 
09:30 – 
10:30
Rheumatoid arthritis
aetiology,
pathogenesis and animal models 
Binvignat,
M (USA)
SINGLE CELL TRANSCRIPTOMICS ANALYSIS OF BLOOD IMMUNE CELLS IDENTIFIES GENE SIGNATURES AND CELL SUBSETS ASSOCIATED WITH DISEASE ACTIVITY IN A DIVERSE POPULATION OF RHEUMATOID ARTHRITIS PATIENTS
Single-cell transcriptomics of RA patients give ground to new effector cell subtypes and targeted therapies towards personalized medicine.
Poster
0354
Saturday,
03.06.2023 10:00 –
11:30
Genetic Determinants
of Clinical Phenotypes
Iwasaki,
T (Japan)
IDENTIFICATION OF SOMATIC MUTATIONS IN PATIENTS WITH ANCA-ASSOCIATED
Induced somatic mutations have not been mapped thoroughly in rheumatic diseases, thus leaving in shadow their disease impact. This is an outstanding approach on their mapping and functional importance in ANCAs.
Poster
0361
Saturday,
03.06.2023 10:00 – 
11:30
Impact of sex on disease pathogenesis and outcomeWang, Z
(Sweden)
COMPREHENSIVE TRANSCRIPTOMIC CHARACTERIZATION REVEALS CORE GENES AND MODULES ASSOCIATED WITH SEX-DEPENDENT MOLECULAR PAIN MECHANISMS IN OSTEOARTHRITIS
Osteoarthritis is a common co-entity of rheumatic diseases, though this is a novel approach to describe its molecular basis and sex-bias.

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